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Coadministration of encorafenib with sensitive CYP3A4 substrates may cause greater toxicity or decreased efficacy of those brokers.cannabidiol will boost the level or result of diazepam by affecting hepatic enzyme CYP2C19 metabolism. Modify Therapy/Monitor Intently. Consider lowering the dose of sensitive CYP2C19 substrates, as clinically ideal, wh